‘Shree’ movie is about what happens when a common man finds himself in the middle of a mysterious scientific experiment that changes his life forever!

Shreedhar Upadhyay (Hussain Kuwajerwala) is an ordinary accountant who is unhappy with his lower middle class status. In love with girl but cannot marry yet as need to make some basic money. He dreams of a better lifestyle for himself and his girlfriend Sonu (Anjali Patil).  Randhawa, a wealthy businessman, in his ceaseless pursuit of power, has zeroed in on Shree as his last guinea pig. Shree is the last piece of puzzle of a scientific experiment, devised by a brilliant scientist, supported by commissioner of police and funded by his boss Randhawa (Rio Kapadia). As luck would have it, his boss offers him the life he aspires to lead, provided Shree gives 12 hours of his time to him for a scientific experiment. Lured in by promise of a bright and successful future, Shree trade in 12 hours of his life! Randhawa offers him 20 lakhs for participating in an experiment which will last for 12 hours. He trusts them and needs the money, excitedly Shree trade in 12 hours of his life.

But as soon as these 12 hours start, he finds that his simple life has been turned upside down! Accused of murdering the scientist, the commissioner of police and many more people, the film follows showing him struggle with various such troubles!